Several Lipid-Related Gene Polymorphisms Interact with Overweight/Obesity to Modulate Blood Pressure Levels

International Journal of Molecular Sciences

Rui-Xing Yin²  Dong-Feng Wu²  Lynn Htet Htet Aung²  Ting-Ting Yan²  Xiao-Li Cao²  Xing-Jiang Long²  Lin Miao⁴  Wan-Ying Liu³  Lin Zhang¹ 

[1] Department of Cardiology, The People’s Hospital of Guilin, Guilin 541001, Guangxi, China; E-Mail:;Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi, China; E-Mails:;Department of Cardiology, The Third Affiliated Hospital, Guangxi Medical University, Nanning 530000, Guangxi, China; E-Mail:;Department of Cardiology, The Fourth Affiliated Hospital, Guangxi Medical University, Liuzhou 545005, Guangxi, China; E-Mail:

关键词: blood pressure;    hypertension;    genetic polymorphism;    overweight;    obesity;    interaction;   

DOI  :  10.3390/ijms130912062

来源: mdpi

【 摘 要 】

Little is known about the interactions of single nucleotide polymorphisms (SNPs) and overweight/obesity on blood pressure levels. The present study was undertaken to detect 10 lipid-related gene SNPs and their interactions with overweight/obesity on blood pressure levels. Genotyping of ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) rs1044925, low density lipoprotein receptor (LDL-R) AvaII hepatic lipase gene (LIPC) −250G > A, endothelial lipase gene (LIPG) 584C > T, methylenetetrahydrofolate reductase (MTHFR) 677C > T, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP) rs3757354, proprotein convertase subtilisin-like kexin type 9 (PCSK9) E670G, peroxisome proliferator-activated receptor delta (PPARD) +294T > C, and Scavenger receptor class B type 1 (SCARB1) rs5888 was performed in 978 normal weight and 751 overweight/obese subjects. The interactions were detected by factorial regression analysis. The genotypes of ACAT-1 AC, LIPC GA and AA, and SCARB1 TT; LDL-R A-A- and LIPC GA; and SCARB1 TT were interacted with overweight/obesity to increase systolic, diastolic blood pressure (SBP, DBP) and pulse pressure (PP) levels; respectively. The genotypes of ACAT-1 CC; ACAT-1 AA and CC were interacted with overweight/obesity to decrease SBP, PP levels (p < 0.01–0.001); respectively. The differences in blood pressure levels between normal weight and overweight/obese subjects might partly result from different interactions of several SNPs and overweight/obesity.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.