Brain Functional Network Architecture Reorganization and Alterations of Positive and Negative Affect, Experiencing Pleasure and Daytime Sleepiness in Cataract Patients after Intraocular Lenses Implantation

Brain Sciences

Waldemar Karwowski¹  Farzad Farahani¹  Magdalena Fafrowicz²  Aleksandra Zyrkowska²  Anna Maria Sobczak²  Natalia Golonka²  Tadeusz Marek²  Halszka Oginska²  Bartosz Bohaterewicz²  Ewa Beldzik²  Joanna Bolsega-Pacud³  Bozena Romanowska-Dixon³  Aleksandra Domagalik⁴  Dominik Bronicki⁵  Marek Rekas⁵ 

[1]Computational Neuroergonomics Laboratory, Department of Industrial Engineering & Management Systems, University of Central Florida, Orlando, FL 32816, USA

[2]Department of Cognitive Neuroscience and Neuroergonomics, Institute of Applied Psychology, Jagiellonian University, 30-348 Kraków, Poland

[3]Department of Ophthalmology and Ocular Oncology, Medical College, Jagiellonian University, 31-008 Kraków, Poland

[4]Malopolska Centre of Biotechnology, Jagiellonian University, 30-387 Kraków, Poland

[5]Ophthalmology Department, Military Institute of Medicine, 04-349 Warsaw, Poland

关键词: neuroimaging;    cataract;    IOL;    fMRI;    FC;    ALFF;   

DOI  :  10.3390/brainsci11101275

来源: DOAJ

【 摘 要 】

Background: Cataracts are associated with progressive blindness, and despite the decline in prevalence in recent years, it remains a major global health problem. Cataract extraction is reported to influence not only perception, attention and memory but also daytime sleepiness, ability to experience pleasure and positive and negative affect. However, when it comes to the latter, the magnitude and prevalence of this effect still remains uncertain. The current study aims to evaluate the hemodynamic basis of daytime sleepiness, ability to experience pleasure and positive and negative affect in cataract patients after the intraocular lens (IOL) implantation. Methods: Thirty-four cataract patients underwent resting-state functional magnetic resonance imaging evaluation before and after cataract extraction and intraocular lens implantation. Both global and local graph metrics were calculated in order to investigate the hemodynamic basis of excessive sleepiness (ESS), experiencing pleasure (SHAPS) as well as positive and negative affect (PANAS) in cataract patients. Results: Eigenvector centrality and clustering coefficient alterations associated with cataract extraction are significantly correlated with excessive sleepiness, experiencing pleasure as well as positive and negative affect. Conclusions: The current study reveals the hemodynamic basis of sleepiness, pleasure and affect in patients after cataract extraction and intraocular lens implantation. The aforementioned mechanism constitutes a proof for changes in functional network activity associated with postoperative vision improvement.

【 授权许可】

Unknown