Neuroplasticity in children and adolescents in response to treatment intervention: A systematic review of the literature

Clinical and Translational Neuroscience

Reviews/Mini-Reviews

Lisa L Weyandt¹  Emily Shepard²  Lauren Thompson³  Shannon E May³  Christine M Clarkin⁴  Bergljot Gyda Gudmundsdottir⁵  Emily Z Holding⁶  Marisa E Marraccini⁶ 

[1] Department of Psychology, Director Interdisciplinary Neuroscience Program, University of Rhode Island, Kingston, RI, USA;Department of Psychology, University of Rhode Island, Kingston, RI, USA;Interdisciplinary Neuroscience Program, Graduate School, University of Rhode Island, Kingston, RI, USA;Physical Therapy Department, University of Rhode Island, Kingston, RI, USA;Interdisciplinary Neuroscience Program, Graduate School, University of Rhode Island, Kingston, RI, USA;School of Education, University of Iceland, Reykjavik, Iceland;School of Education, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;

关键词: Neuroplasticity;    neuroimaging;    children;    adolescents;    experience-dependent;    sensory-motor;    fMRI;   

DOI  :  10.1177/2514183X20974231

来源: Sage Journals

【 摘 要 】

The purpose of the present study was to conduct a systematic review of the literature, adhering to PRISMA guidelines, regarding evidence of neuroplasticity in children and adolescents in response to cognitive or sensory-motor interventions. Twenty-eight studies employing seven different types of neuroimaging techniques were included in the review. Findings revealed that significant variability existed across the 28 studies with regard to the clinical populations examined, type of interventions employed, neuroimaging methods, and the type of neuroimaging data included in the studies. Overall, results supported that experience-dependent interventions were associated with neuroplastic changes among children and adolescents in both neurotypical and clinical populations. However, it remains unclear whether these molecular neuroplastic changes, including the degree and direction of those differences, were the direct result of the intervention. Although the findings are encouraging, methodological limitations of the studies limit clinical utility of the results. Future studies are warranted that rigorously define the construct of neuroplasticity, establish consistent protocols across measurement techniques, and have adequate statistical power. Lastly, studies are needed to identify the functional and structural neuroplastic mechanisms that correspond with changes in cognition and behavior in child and adolescent samples.

【 授权许可】

CC BY-NC   
© The Author(s) 2020

【 图 表 】

Figure 3.

Figure 3.