Preventive effect of fermented brown rice and rice bran on spontaneous type 1 diabetes in NOD female mice

Journal of Functional Foods

Akiko Sakurai¹  Hideyuki Nemoto²  Masataka Shikanai³  Koji Yasutomo⁴  Keiko Kataoka⁵ 

[1] Corresponding author at: Department of Microbiology and Genetic Analysis, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan.;Department of Immunology and Parasitology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan;Koken Co., Ltd., 329 Nakagoya, Toubetsu, Hokkaido 061-0211, Japan;Department of Immunology and Parasitology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan;Department of Microbiology and Genetic Analysis, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan;

关键词: Fermented brown rice;    Insulitis;    NOD mouse;    Pdx1;    Type 1 diabetes;   

DOI  :  

来源: DOAJ

【 摘 要 】

Consumption of brown rice and rice bran fermented with Aspergillus oryzae (FBRA) suppresses spontaneously occurring diabetes in female NOD mouse. While control diet-fed mice showed glucosuria and hyperglycemia at around 20 week of age and the ratio reached to 57% at 30 weeks of age, the ratio did not increase in the 0.5% FBRA-containing diet-fed group. The FBRA-fed group at 30 weeks of age kept higher ratio of intact islets and showed significantly lower insulitis score compared to the control diet group, with dose-dependency from 0.25% to 0.5% dietary concentration of FBRA. The percentage of diabetic mice was significantly lower at 24 weeks of age as compared to the control group (p = 0.01, log rank test). These results indicate that the suppressive effects of dietary administration of 0.5% FBRA in delaying the spontaneous onset of diabetes in NOD mice is probably achieved by maintaining the number of intact islets.

【 授权许可】

Unknown