期刊论文详细信息
mSphere
mSphere of Influence: Evolutionary Strategies To Sensitize Drug-Resistant Pathogens
Rebecca S. Shapiro1 
[1] Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada;
关键词: antibiotics;    antimicrobial drug resistance;    collateral sensitivity;    experimental evolution;    microbial pathogens;   
DOI  :  10.1128/mSphere.00313-19
来源: DOAJ
【 摘 要 】

ABSTRACT Rebecca S. Shapiro studies antimicrobial resistance and genetic interaction networks. In this mSphere of Influence article, she reflects on how the papers “Bacterial evolution of antibiotic hypersensitivity” by Lázár et al. (V. Lázár, G. Pal Singh, R. Spohn, I. Nagy, et al., Mol Syst Biol 9:700, 2013, https://doi.org/10.1038/msb.2013.57) and “Use of collateral sensitivity networks to design drug cycling protocols that avoid resistance development” by L. Imamovic and M. O. A. Sommer (Sci Transl Med 5:204ra132, 2013, https://doi.org/10.1126/scitranslmed.3006609) impacted her thinking about multigene interaction effects on drug resistance.

【 授权许可】

Unknown   

  文献评价指标  
  下载次数:0次 浏览次数:0次