Antiviral Effect of Resveratrol in Piglets Infected with Virulent Pseudorabies Virus

Viruses

Guizhou Yue¹  Yin Wang²  Renyong Jia²  Xiaoxia Liang³  Yuanfeng Zou³  Bo Jing³  Xu Song³  Gang Ye³  Lizi Yin³  Lixia Li³  Wenzhi Tong³  Changliang He³  Zhongqiong Yin³  Xinghong Zhao³  Juchun Lin³  Cheng Lv³ 

[1] College of Science, Sichuan Agricultural University, Ya’an 625014, China;Key laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China;Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China;

关键词: antiviral activity;    resveratrol;    virulent pseudorabies virus;    piglets;   

DOI  :  10.3390/v10090457

来源: DOAJ

【 摘 要 】

Pseudorabies virus (PRV) is one of the most important pathogens of swine, resulting in devastating disease and economic losses worldwide. Nevertheless, there are currently no antiviral drugs available for PRV infection. Resveratrol (Res) was identified to exert its antiviral activity by inhibiting the PRV replication in preliminary investigations. In our previous study, we found that Res has anti-PRV activity in vitro. Here, we show that Res can effectively reduce the mortality and increase the growth performance of PRV-infected piglets. After Res treatment, the viral loads significantly (p < 0.001) decreased. Pathological symptoms, particularly inflammation in the brain caused by PRV infection, were significantly (p < 0.001) relieved by the effects of Res. In Res-treated groups, higher levels of cytokines in serum, including interferon gama, interleukin 12, tumor necrosis factor-alpha and interferon alpha were observed at 7 days post infection. These results indicated that Res possesses potent inhibitory activity against PRV-infection through inhibiting viral reproduction, alleviating PRV-induced inflammation and enhancing animal immunity, suggesting that Res is expected to be a new alternative control measure for PRV infection.

【 授权许可】

Unknown