Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle

Molecules

Ching-Yi Yiu¹  Shih-Ying Chen¹  Li-Kwan Chang¹  Ya-Fang Chiu¹ 

[1] ¹Department of Otolaryngology, Chi Mei Medical Center, Liouying, Tainan, 717, Taiwan

关键词: resveratrol;    antiviral activity;    EBV;   

DOI  :  10.3390/molecules15107115

来源: mdpi

【 摘 要 】

Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and reduces viron production, suggesting that this compound may be useful for preventing the proliferation of the virus.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.