Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”

Critical Care

Chiara Robba¹  Paolo Pelosi¹  Rafael Badenes²  Daniel Agustin Godoy³ 

[1] Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences;Anesthesiology and Surgical-Trauma Intensive Care, University Clinic Hospital;Neurointensive Care Unit, Sanatorio Pasteur;

关键词: Ketamine;    Traumatic brain injury;    Sedation;    Agitation;    Secondary insult;    Cooperative sedation;   

DOI  :  10.1186/s13054-020-03452-x

来源: DOAJ

【 摘 要 】

Abstract Maintaining an adequate level of sedation and analgesia plays a key role in the management of traumatic brain injury (TBI). To date, it is unclear which drug or combination of drugs is most effective in achieving these goals. Ketamine is an agent with attractive pharmacological and pharmacokinetics characteristics. Current evidence shows that ketamine does not increase and may instead decrease intracranial pressure, and its safety profile makes it a reliable tool in the prehospital environment. In this point of view, we discuss different aspects of the use of ketamine in the acute phase of TBI, with its potential benefits and pitfalls.

【 授权许可】

Unknown