期刊论文详细信息
Molecules
Recent Advances in Tannic Acid (Gallotannin) Anticancer Activities and Drug Delivery Systems for Efficacy Improvement; A Comprehensive Review
Ping Shao1  NermeenA. Elkasabgy2  Rabab Kamel3  MohamedA. Farag4  RanaA. Youness5 
[1] Department of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China;Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt;Pharmaceutical Technology Department, National Research Centre, Cairo 12622, Egypt;Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr El Aini Street, Cairo 11562, Egypt;The Molecular Genetics Research Team, Department of Pharmaceutical Biology, Faculty of Pharmacy and Biotechnology, German University in Cairo, New Cairo City, Cairo 12622, Egypt;
关键词: tannic acid;    anticancer;    combinatorial effects;    drug delivery systems;    nanoparticles;    molecular mechanisms;   
DOI  :  10.3390/molecules26051486
来源: DOAJ
【 摘 要 】

Tannic acid is a chief gallo-tannin belonging to the hydrolysable tannins extracted from gall nuts and other plant sources. A myriad of pharmaceutical and biological applications in the medical field has been well recognized to tannic acid. Among these effects, potential anticancer activities against several solid malignancies such as liver, breast, lung, pancreatic, colorectal and ovarian cancers have been reported. Tannic acid was found to play a maestro-role in tuning several oncological signaling pathways including JAK/STAT, RAS/RAF/mTOR, TGF-β1/TGF-β1R axis, VEGF/VEGFR and CXCL12/CXCR4 axes. The combinational beneficial effects of tannic acid with other conventional chemotherapeutic drugs have been clearly demonstrated in literature such as a synergistic anticancer effect and enhancement of the chemo-sensitivity in several resistant cases. Yet, clinical applications of tannic acid have been limited owing to its poor lipid solubility, low bioavailability, off-taste, and short half-life. To overcome such obstacles, novel drug delivery systems have been employed to deliver tannic acid with the aim of improving its applications and/or efficacy against cancer cells. Among these drug delivery systems are several types of organic and metallic nanoparticles. In this review, the authors focus on the molecular mechanisms of tannic acid in tuning several neoplastic diseases as well as novel drug delivery systems that can be used for its clinical applications with an attempt to provide a systemic reference to promote the development of tannic acid as a cheap drug and/or drug delivery system in cancer management.

【 授权许可】

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