Malnutrition and Fracture Healing: Are Specific Deficiencies in Amino Acids Important in Nonunion Development?

Nutrients

KarolinaA.P. Wijnands¹  DennisM. Meesters¹  PeterR.G. Brink¹  Martijn Poeze¹ 

[1] Department of Surgery, Maastricht University Medical Center, P.O. Box 616, 6200 MD Maastricht, The Netherlands;

关键词: fracture healing;    nonunion;    arginine;    citrulline;    nitric oxide;    nitric oxide synthase;   

DOI  :  10.3390/nu10111597

来源: DOAJ

【 摘 要 】

With the increasing incidence of fractures now, and in the future, the absolute number of bone-healing complications such as nonunion development will also increase. Next to fracture-dependent factors such as large bone loss volumes and inadequate stabilization, the nutritional state of these patients is a major influential factor for the fracture repair process. In this review, we will focus on the influence of protein/amino acid malnutrition and its influence on fracture healing. Mainly, the arginine-citrulline-nitric oxide metabolism is of importance since it can affect fracture healing via several precursors of collagen formation, and through nitric oxide synthases it has influences on the bio-molecular inflammatory responses and the local capillary growth and circulation.

【 授权许可】

Unknown