The role of necroptosis in neurosurgical diseases

Brazilian Journal of Medical and Biological Research

关键词: Molecular mechanism;    Pathogenesis;    Programmed cell death;    Therapy;   

DOI  :  10.1590/1414-431X20144310

来源: DOAJ

【 摘 要 】

Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection after traumatic and ischemic brain injury. Therefore, the necroptotic pathway represents a potential target for neurological diseases that are managed by neurosurgeons. In this review, we summarize recent advances in the understanding of necroptotic signaling pathways and explore the role of necroptotic cell death in craniocerebral trauma, brain tumors, and cerebrovascular diseases.

【 授权许可】

Unknown