Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups

Brain and Behavior

Miranda Olff¹  Gina L. Forster²  Kelene A. Fercho³  Raluca M. Simons³  Lee A. Baugh³  Jeffrey S. Simons³  Richard J. Davidson⁴  James H. Cole⁵  Lianne Schmaal⁶  John H. Krystal⁷  Chadi G. Abdallah⁷  Christopher L. Averill⁷  Yuval Neria⁸  Xiaofu He⁸  Benjamin Suarez‐Jimenez⁸  Xi Zhu⁸  Sven C. Mueller⁹  Jean Théberge^1,10  Richard W. J. Neufeld^1,11  Ruth Lanius^1,11  Saskia B.J. Koch^1,12  Mirjam vanZuiden^1,12  Laura Nawijn^1,12  Jessie L. Frijling^1,12  Dick J. Veltman^1,13  Laura K. M. Han^1,14  Lauren A. M. Lebois^1,15  Kerry Ressler^1,15  Scott R. Sponheim^1,16  Seth Disner^1,16  Martha E. Shenton^1,17  Maria Densmore^1,18  K. Luan Phan^1,19  Tanja Jovanovic^2,20  Timothy D. Ely^2,21  Sanne vanRooij^2,21  Negar Fani^2,21  Jennifer S. Stevens^2,21  Adi Maron‐Katz^2,22  Amit Etkin^2,22  Jennifer Urbano Blackford^2,23  Gen Li^2,24  Bunmi O. Olatunji^2,25  Christian Schmahl^2,26  Julia Herzog^2,26  Vincent A. Magnotta^2,27  Milissa L. Kaufman^2,28  Molly Monsour^2,29  Isabelle M. Rosso^3,30  Elizabeth A. Olson^3,30  Paul M. Thompson^3,31  Lauren Salminen^3,31  Justin T. Baker^3,32  Thomas Straube^3,33  David Hofmann^3,33  Jacklynn Fitzgerald^3,34  Terri deRoon‐Cassini^3,35  Serena Bonomo^3,36  Murray Stein^3,37  Jessica A. Bomyea^3,38  Henrik Walter^3,39  Anika Sierk^3,39  Antje Manthey^3,39  Judith K. Daniels^4,40  Christine Larson^4,41  Courtney C. Haswell^4,42  Emily Clarke Rubright^4,42  Ashley N. Clausen^4,42  Amanda A. Watts^4,42  Rajendra A. Morey^4,42  M. Nicole Buckley^4,42 

[1] ARQ National Psychotrauma Centrum Diemen The Netherlands;Brain Health Research Centre Department of Anatomy University of Otago Dunedin New Zealand;Center for Brain and Behavior Research University of South Dakota Vermillion South Dakota USA;Center for Healthy Minds Departments of Psychology and Psychiatry University of Wisconsin‐Madison Madison Wisconsin USA;Centre for Medical Image Computing Computer Science University College London London UK;Centre for Youth Mental Health The University of Melbourne Melbourne Australia;Clinical Neuroscience Division National Center for PTSD West Haven Connecticut USA;Columbia University Medical Center Manhattan New York USA;Department of Experimental Clinical and Health Psychology Ghent University Ghent Belgium;Department of Medical Biophysics University of Western Ontario London Ontario Canada;Department of Neuroscience Western University London Ontario Canada;Department of Psychiatry Amsterdam University Medical Centers Location Academic Medical Center Amsterdam Neuroscience University of Amsterdam Amsterdam The Netherlands;Department of Psychiatry Amsterdam University Medical Centers Location VU University Medical Center VU University Amsterdam The Netherlands;Department of Psychiatry Amsterdam University Medical Centers VU University Medical Center GGZ inGeest Amsterdam Neuroscience Amsterdam The Netherlands;Department of Psychiatry Harvard Medical School Boston Massachusetts USA;Department of Psychiatry University of Minnesota Medical School Minneapolis Minnesota USA;Department of Psychiatry VA Boston Healthcare System Brockton Massachusetts USA;Department of Psychiatry Western University London Ontario Canada;Department of Psychiatry and Behavioral Health The Ohio State University Columbus Ohio USA;Department of Psychiatry and Behavioral Neurosciences Wayne State University Detroit Michigan USA;Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA;Department of Psychiatry and Behavioral Sciences Stanford University of Medicine Stanford California USA;Department of Psychiatry and Behavioral Sciences Vanderbilt University Medical Center Nashville Tennessee USA;Department of Psychology University of Chinese Academy of Sciences Beijing China;Department of Psychology Vanderbilt University Nashville Tennessee USA;Department of Psychosomatic Medicine and Psychotherapy Central Institute of Mental Health Medical Faculty Mannheim/Heidelberg University Mannheim Germany;Departments of Radiology Psychiatry and Biomedical Engineering University of Iowa Iowa City Iowa USA;Division of Women's Mental Health McLean Hospital Belmont Massachusetts USA;Duke University Brain Imaging and Analysis Center Durham North Carolina USA;Harvard Medical School Boston Massachusetts USA;Imaging Genetics Center Mark & Mary Stevens Neuroimaging & Informatics Institute Keck School of Medicine University of Southern California Marina del Rey California USA;Institute for Technology in Psychiatry McLean Hospital Harvard University Belmont Massachusetts USA;Institute of Medical Psychology and Systems Neuroscience University of Muenster Muenster Germany;Marquette University Milwaukee Wisconsin USA;Medical College of Wisconsin Milwaukee Wisconsin USA;New York State Psychiatric Institute New York New York USA;UC San Diego Department of Family Medicine and Public Health San Deigo California USA;UC San Diego Department of Psychiatry San Deigo California USA;University Medical Centre Charite Berlin Germany;University of Groningen The Netherlands;University of Wisconsin‐Milwaukee Milwaukee Wisconsin USA;VA Mid‐Atlantic Mental Illness Research Education, and Clinical Center Durham North Carolina USA;

关键词: aging;    machine learning;    mega‐analysis;    neuroimaging;    posttraumatic stress disorder;    trauma;   

DOI  :  10.1002/brb3.2413

来源: DOAJ

【 摘 要 】

Abstract Background Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobiology of aging in the context of PTSD. Method Adult subjects (N = 2229; 56.2% male) aged 18–69 years (mean = 35.6, SD = 11.0) from 21 ENIGMA‐PGC PTSD sites underwent T1‐weighted brain structural magnetic resonance imaging, and PTSD assessment (PTSD+, n = 884). Previously trained voxel‐wise (brainageR) and region‐of‐interest (BARACUS and PHOTON) machine learning pipelines were compared in a subset of control subjects (n = 386). Linear mixed effects models were conducted in the full sample (those with and without PTSD) to examine the effect of PTSD on brain predicted age difference (brain PAD; brain age − chronological age) controlling for chronological age, sex, and scan site. Results BrainageR most accurately predicted brain age in a subset (n = 386) of controls (brainageR: ICC = 0.71, R = 0.72, MAE = 5.68; PHOTON: ICC = 0.61, R = 0.62, MAE = 6.37; BARACUS: ICC = 0.47, R = 0.64, MAE = 8.80). Using brainageR, a three‐way interaction revealed that young males with PTSD exhibited higher brain PAD relative to male controls in young and old age groups; old males with PTSD exhibited lower brain PAD compared to male controls of all ages. Discussion Differential impact of PTSD on brain PAD in younger versus older males may indicate a critical window when PTSD impacts brain aging, followed by age‐related brain changes that are consonant with individuals without PTSD. Future longitudinal research is warranted to understand how PTSD impacts brain aging across the lifespan.

【 授权许可】

Unknown