Molecular Mechanisms and Epigenetic Regulation in Diabetic Cardiomyopathy

Frontiers in Cardiovascular Medicine

Rajni Garg¹  Ajay Bahl²  Madhu Khullar³  Anupam Mittal⁴ 

[1] Council of Scientific and Industrial Research - Institute of Microbial Technology, Chandigarh, India;Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India;Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India;Department of Translational and Regenerative Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India;

关键词: diabetes mellitus;    diabetic cardiomyopathy;    apoptosis;    oxidative stress;    mitochondrial function;    cardiac remodeling;   

DOI  :  10.3389/fcvm.2021.725532

来源: DOAJ

【 摘 要 】

Diabetes mellitus (DM) is an important lifestyle disease. Type 2 diabetes is one of the prime contributors to cardiovascular diseases (CVD) and diabetic cardiomyopathy (DbCM) and leads to increased morbidity and mortality in patients with DM. DbCM is a typical cardiac disease, characterized by cardiac remodeling in the presence of DM and in the absence of other comorbidities such as hypertension, valvular diseases, and coronary artery disease. DbCM is associated with defective cardiac metabolism, altered mitochondrial structure and function, and other physiological and pathophysiological signaling mechanisms such as oxidative stress, inflammation, myocardial apoptosis, and autophagy. Epigenetic modifiers are crucial players in the pathogenesis of DbCM. Thus, it is important to explore the role of epigenetic modifiers or modifications in regulating molecular pathways associated with DbCM. In this review, we have discussed the role of various epigenetic mechanisms such as histone modifications (acetylation and methylation), DNA methylation and non-coding RNAs in modulating molecular pathways involved in the pathophysiology of the DbCM.

【 授权许可】

Unknown