Physical Exercise as Personalized Medicine for Dementia Prevention?

Frontiers in Physiology

Marco Taubert¹  Notger G. Müller³  Patrick Müllers⁴ 

[1] Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany;Institute of Sport Science, Otto-von-Guericke University Magdeburg, Magdeburg, Germany;Medical Faculty, Clinic for Neurology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany;Neuroprotection Laboratory, German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany;

关键词: exercise;    dementia;    neuroplasticity;    personalized medicine;    responder;   

DOI  :  10.3389/fphys.2019.00672

来源: DOAJ

【 摘 要 】

Accumulating evidence mainly from observational studies supports the notion that lifestyle factors such as regular physical activity can modulate potential risk factors of dementia. Regarding a potential mechanism for this interaction, results from intervention studies show that exercising can induce neuroplastic changes in the human brain. However, a detailed look at the study results reveals a wide interindividual variability in the observed effects. This heterogeneity may originate from the fact that there are “responders” and “non-responders” with respect to the impact of physical exercise on physiological outcome parameters (i.e., VO2 peak) and the brain. From this, it follows that recommendations for physical exercise programs should not follow a “one size fits all” approach. Instead, we propose that the exercises should be tailored to an individual in order to maximize the potential neuroplastic and preventive effects of regular exercise. These adaptations should take the individual performance levels into account and impact both the quality (i.e., type) and the quantity of exercises (i.e., intensity, duration, and volume).

【 授权许可】

Unknown