The potential therapy with dental tissue-derived mesenchymal stem cells in Parkinson’s disease

Stem Cell Research & Therapy

Zhuangzhuang Xiao¹  Wangyu Bi¹  Tong Lei¹  Hongwu Du¹  Yanjie Yang¹  Yanyan Liu² 

[1] 112 Lab, School of Chemistry and Biological Engineering, University of Science and Technology Beijing;Kangyanbao (Beijing) Stem Cell Technology Co., Ltd;

关键词: Cell therapy;    Dopaminergic neurons;    Dental pulp stem cells;    Parkinson’s disease;    Stem cells from human exfoliated deciduous teeth;   

DOI  :  10.1186/s13287-020-01957-4

来源: DOAJ

【 摘 要 】

Abstract Parkinson’s disease (PD), the second most common neurodegenerative disease worldwide, is caused by the loss of dopaminergic (DAergic) neurons in the substantia nigra resulting in a series of motor or non-motor disorders. Current treatment methods are unable to stop the progression of PD and may bring certain side effects. Cell replacement therapy has brought new hope for the treatment of PD. Recently, human dental tissue-derived mesenchymal stem cells have received extensive attention. Currently, dental pulp stem cells (DPSCs) and stem cells from human exfoliated deciduous teeth (SHED) are considered to have strong potential for the treatment of these neurodegenerative diseases. These cells are considered to be ideal cell sources for the treatment of PD on account of their unique characteristics, such as neural crest origin, immune rejection, and lack of ethical issues. In this review, we briefly describe the research investigating cell therapy for PD and discuss the application and progress of DPSCs and SHED in the treatment of PD. This review offers significant and comprehensive guidance for further clinical research on PD.

【 授权许可】

Unknown