Preparation and Drug Release Profile of Chitosan–Siloxane Hybrid Capsules Coated with Hydroxyapatite

Pharmaceutics

Yuki Shirosaki¹  Satoshi Hayakawa²  Akiyoshi Osaka³  Kohei Okamoto³  Yasuyo Tsukatani³ 

[1] Faculty of Engineering, Kyushu Institute of Technology, 1-1 Sensuicho, Tobata-ku, Kitakyushu 804-8550, Japan;Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama 700-8530, Japan;Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan;

关键词: chitosan–siloxane hybrid;    capsule;    hydroxyapatite coating;    drug release;   

DOI  :  10.3390/pharmaceutics14051111

来源: DOAJ

【 摘 要 】

Chitosan is a cationic polymer that forms polymerized membranes upon reaction with anionic polymers. Chitosan−carboxymethyl cellulose (CMC) capsules are drug delivery carrier candidates whose mechanical strength and permeability must be controlled to achieve sustained release. In this study, the capsules were prepared from chitosan−γ-glycidoxypropyltrimethoxysilane (GPTMS)−CMC. The mechanical stability of the capsules was improved by crosslinking the chitosan with GPTMS. The capsules were then coated with hydroxyapatite (HAp) by alternately soaking them in calcium chloride solution and disodium hydrogen phosphate solution to prevent rapid initial drug release. Cytochrome C (CC), as a model drug, was introduced into the capsules via two routes, impregnation and injection, and then the CC released from the capsules was examined. HAp was found to be deposited on the internal and external surfaces of the capsules. The amount of CC introduced, and the release rate were reduced by the HAp coating. The injection method was found to result in the greatest CC loading.

【 授权许可】

Unknown