Comparison of Various Solvent Extracts and Major Bioactive Components from Portulaca oleracea for Antioxidant, Anti-Tyrosinase, and Anti-α-Glucosidase Activities

Antioxidants

Hsiang-Ru Lin¹  Shih-Wei Wang²  Wei-Cheng Chen²  Jih-Jung Chen³  Chang-Syun Yang³  Tzong-Huei Lee⁴  Yi-Cheng Chu⁵  Cai-Wei Li⁵ 

[1] Department of Chemistry, College of Science, National Kaohsiung Normal University, Kaohsiung 824, Taiwan;Department of Medicine, MacKay Medical College, New Taipei City 252, Taiwan;Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan;Institute of Fisheries Science, National Taiwan University, Taipei 106, Taiwan;Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan;

关键词: Portulaca oleracea;    various solvent extracts;    major bioactive components;    antioxidant activity;    anti-α-glucosidase activity;    anti-tyrosinase activity;   

DOI  :  10.3390/antiox11020398

来源: DOAJ

【 摘 要 】

Portulaca oleracea is a well-known species for traditional medicine and food homology in Taiwan. In traditional medicine, P. oleracea is also used to treat gastrointestinal disorders, liver inflammation, fever, severe inflammation, and headaches. We investigated antioxidant, anti-tyrosinase, and anti-α-glucosidase activities of various solvent extracts and major bioactive components from P. oleracea. Ethanol and acetone extracts showed potent DPPH, ABTS, and hydroxyl radical scavenging activities. Chloroform and n-hexane extracts displayed significant superoxide radical scavenging activity. Furthermore, ethyl acetate and acetone extracts of P. oleracea showed potent anti-tyrosinase and anti-α-glucosidase activities. Examined and compared to the various solvent extracts for their chemical compositions using HPLC analysis, we isolated seven major compounds and analyzed their antioxidant, anti-tyrosinase, and anti-α-glucosidase activities. Seven active compounds of P. oleracea, especially quercetin, rosmarinic acid, and kaempferol, exhibited obvious antioxidant, anti-tyrosinase, and anti-α-glucosidase activities. The molecular docking model and the hydrophilic interactive mode of tyrosinase and α-glucosidase revealed that active compounds might have a higher antagonistic effect than commonly inhibitors. Our result shows that the active solvent extracts and their components of P. oleracea have the potential as natural antioxidants, tyrosinase and α-glucosidase inhibitors. Our results suggest that the active solvent extracts of P. oleracea and their components have potential as natural antioxidants, tyrosinase and α-glucosidase inhibitors.

【 授权许可】

Unknown