Mitochondrial dynamics in the pathogenesis of diabetic complications

Di-san junyi daxue xuebao

QU Hua¹  ZHENG Hongting¹ 

[1] Department of Endocrinology, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China ;

关键词: mitochondrial dynamics;    diabetes mellitus;    diabetic ulcers;    diabetic nephropathy;    diabetic cardiomyopathy;   

DOI  :  10.16016/j.1000-5404.202111211

来源: DOAJ

【 摘 要 】

Mitochondrial dynamics is the process of mitochondrial fusion and division to maintain dynamic balance. In recent years, it has been found that this dynamic change plays an important role in regulating mitochondrial morphology and quantity, mitochondrial oxidative metabolism, membrane potential and energy production. In diabetes, hyperglycemia significantly interferes with the dynamic balance of mitochondrial fusion and division process, and affects the quantity, morphology and function of mitochondria. And ultimately, the dynamic change of mitochondria is closely related to many chronic complications of diabetes, but the specific mechanism remains unclear. Our research group has long been committed to exploring the roles and mechanisms of mitochondrial dynamics in a variety of diabetic complications. This review summarizes the research progress and potential mechanisms of mitochondrial dynamics in diabetic ulcers, diabetic nephropathy and diabetic cardiomyopathy.

【 授权许可】

Unknown