The Genetics of Diabetic Nephropathy

Genes

Eoin Brennan¹  Caitríona McEvoy¹  Denise Sadlier²  Catherine Godson¹ 

[1] Diabetes Complications Research Centre, Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland; E-Mails:;Mater Misericordiae Hospital, Dublin, Ireland; E-Mail:

关键词: diabetes mellitus;    diabetic nephropathy;    genome-wide association study;    single nucleotide polymorphism;   

DOI  :  10.3390/genes4040596

来源: mdpi

【 摘 要 】

Up to 40% of patients with type 1 and type 2 diabetes will develop diabetic nephropathy (DN), resulting in chronic kidney disease and potential organ failure. There is evidence for a heritable genetic susceptibility to DN, but despite intensive research efforts the causative genes remain elusive. Recently, genome-wide association studies have discovered several novel genetic variants associated with DN. The identification of such variants may potentially allow for early identification of at risk patients. Here we review the current understanding of the key molecular mechanisms and genetic architecture of DN, and discuss the merits of employing an integrative approach to incorporate datasets from multiple sources (genetics, transcriptomics, epigenetic, proteomic) in order to fully elucidate the genetic elements contributing to this serious complication of diabetes.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.