Synthesis, characterization, and antibacterial studies of pipemidic acid metal complexes

Future Journal of Pharmaceutical Sciences

Agha Zeeshan Mirza¹  Ahsan Zamir Siddiqi² 

[1] Chemistry Department, Faculty of Applied Sciences, Umm Al-Qura University;Research Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi;

关键词: Pipemidic acid;    Metal complexes;    Antibacterial studies;   

DOI  :  10.1186/s43094-021-00301-8

来源: DOAJ

【 摘 要 】

Abstract Background Pipemidic acid, like other quinolones, is susceptible against different organisms in vitro, and it was proved to be a preferred choice for certain indications. Previous studies reveal that concurrent administration of essential and trace elements with quinolones decreases gastrointestinal absorption, causing therapeutic failure. To study the probable interaction of pipemidic acid with essential and trace elements present in the human body, pipemidic acid has been reacted with magnesium, calcium, chromium, manganese, iron, cobalt, nickel, copper, zinc, and cadmium, the complexes formed. Results The compounds were characterized by the melting point, conductance studies, IR, UV, 1H-NMR, CHN, and atomic absorption analysis. Conclusion The results suggested oxygen atoms present at carbonyl and carboxylic group render the bidentate6 property to the pipemidic acid. The antimicrobial activity of the compounds was determined by the disk diffusion method, and both standard and complexes show no antibacterial activity against the clinical isolates.

【 授权许可】

Unknown