Advances in ER-Phagy and Its Diseases Relevance

Cells

Xuehong Qian¹  Yixian Cui¹  Lingang He¹ 

[1] Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, China;

关键词: ER-phagy;    receptor;    neurodegenerative diseases;    cancer;    metabolic diseases;   

DOI  :  10.3390/cells10092328

来源: DOAJ

【 摘 要 】

As an important form of selective autophagy in cells, ER-phagy (endoplasmic reticulum-selective autophagy), the autophagic degradation of endoplasmic reticulum (ER), degrades ER membranes and proteins to maintain cellular homeostasis. The relationship between ER-phagy and human diseases, including neurodegenerative disorders, cancer, and other metabolic diseases has been unveiled by extensive research in recent years. Starting with the catabolic process of ER-phagy and key mediators in this pathway, this paper reviews the advances in the mechanism of ER-phagy and its diseases relevance. We hope to provide some enlightenment for further study on ER-phagy and the development of novel therapeutic strategies for related diseases.

【 授权许可】

Unknown