Sorcin, a Calcium Binding Protein Involved in the Multidrug Resistance Mechanisms in Cancer Cells

Molecules

Gianni Colotti²  Elena Poser¹  Annarita Fiorillo¹  Ilaria Genovese¹  Valerio Chiarini¹ 

[1]Department Biochemical Sciences “A. Rossi Fanelli”, University Sapienza, P.le A. Moro 5, Rome 00185, Italy

[2] E-Mails:

[3]Institute of Biology, Molecular Medicine and Nanobiotechnology, Consiglio Nazionale delle Ricerche, P.le A Moro 5, Rome 00185, Italy

[4] E-Mail:

关键词: sorcin;    calcium;    cancer;    multi-drug resistance in cancer;    endoplasmic reticulum;    heart;    brain;    neurodegenerative diseases;    ryanodine receptors;    ER stress;   

DOI  :  10.3390/molecules190913976

来源: mdpi

【 摘 要 】

Sorcin is a penta-EF hand calcium binding protein, which participates in the regulation of calcium homeostasis in cells. Sorcin regulates calcium channels and exchangers located at the plasma membrane and at the endo/sarcoplasmic reticulum (ER/SR), and allows high levels of calcium in the ER to be maintained, preventing ER stress and possibly, the unfolded protein response. Sorcin is highly expressed in the heart and in the brain, and overexpressed in many cancer cells. Sorcin gene is in the same amplicon as other genes involved in the resistance to chemotherapeutics in cancer cells (multi-drug resistance, MDR) such as ABCB4 and ABCB1; its overexpression results in increased drug resistance to a number of chemotherapeutic agents, and inhibition of sorcin expression by sorcin-targeting RNA interference leads to reversal of drug resistance. Sorcin is increasingly considered a useful marker of MDR and may represent a therapeutic target for reversing tumor multidrug resistance.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.