Sarcopenia and Myosteatosis Are Associated with Neutrophil to Lymphocyte Ratio but Not Glasgow Prognostic Score in Colorectal Cancer Patients

Journal of Clinical Medicine

Anne Tuomisto¹  Juha P. Väyrynen¹  Markus J. Mäkinen¹  Päivi Sirniö¹  Vesa-Matti Pohjanen¹  Kai Klintrup²  Reetta Häivälä²  Sanna Meriläinen²  Elisa Mäkäräinen²  Raila Aro²  Juha Saarnio²  Tero T. Rautio²  Karl-Heinz Herzig³ 

[1] Cancer and Translational Medicine Research Unit, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland;Department of Surgery, Oulu University Hospital, 90014 Oulu, Finland;Oulu University Hospital, Medical Research Center Oulu, P.O. Box 21, 90029 Oulu, Finland;

关键词: sarcopenia;    myosteatosis;    cytokines;    systemic inflammation;    NLR;   

DOI  :  10.3390/jcm11092656

来源: DOAJ

【 摘 要 】

Cancer patients commonly present sarcopenia, myosteatosis, and systemic inflammation, which are risk factors of poor survival. In this study, sarcopenia and myosteatosis were defined from preoperative body computed tomography scans of 222 colorectal cancer (CRC) patients and analyzed in relation to tumor and patient characteristics, markers of systemic inflammation (modified Glasgow prognostic score (mGPS), neutrophil–lymphocyte ratio (NLR), serum levels of C-reactive protein (CRP), albumin, and 13 cytokines, and survival. Of the systemic inflammation markers, sarcopenia and/or myosteatosis associated with elevated NLR (p = 0.005) and low albumin levels (≤35 g/L) (p = 0.018), but not with mGPS or serum cytokine levels. In addition, myosteatosis was associated with a proximal tumor location (p = 0.039), serrated tumor subtype (p < 0.001), and severe comorbidities (p = 0.004). Multivariable analyses revealed that severe comorbidities and serrated histology were independent predictors of myosteatosis, and older age and elevated NLR were independent indicators of sarcopenia. Myosteatosis associated with shorter overall survival in univariable analysis (HR 1.959, 95% CI 1.24–3.10, p = 0.004) but not in multivariable analysis (p = 0.075). We conclude that sarcopenia and myosteatosis were associated with inflammatory marker NLR, but not with mGPS. Moreover, patients with serrated CRC may have an increased risk of myosteatosis. Myosteatosis or sarcopenia were not independent predictors of patient survival.

【 授权许可】

Unknown