Nanoparticles in Targeted Alpha Therapy

Nanomaterials

Agnieszka Majkowska-Pilip¹  Aleksander Bilewicz¹  Kamil Wawrowicz¹  Weronika Gawęda¹  Kinga Żelechowska-Matysiak¹ 

[1] Centre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland;

关键词: α-emitters;    radiopharmaceuticals;    nanoparticles;    nanomedicine;    targeted therapy;    tumour;   

DOI  :  10.3390/nano10071366

来源: DOAJ

【 摘 要 】

Recent advances in the field of nanotechnology application in nuclear medicine offer the promise of better therapeutic options. In recent years, increasing efforts have been made on developing nanoconstructs that can be used as carriers for immobilising alpha (α)-emitters in targeted drug delivery. In this publication, we provide a comprehensive overview of available information on functional nanomaterials for targeted alpha therapy. The first section describes why nanoconstructs are used for the synthesis of α-emitting radiopharmaceuticals. Next, we present the synthesis and summarise the recent studies demonstrating therapeutic applications of α-emitting labelled radiobioconjugates in targeted therapy. Finally, future prospects and the emerging possibility of therapeutic application of radiolabelled nanomaterials are discussed.

【 授权许可】

Unknown