Detection of ketorolac drug using pencil graphite electrode

Biomedical Engineering Advances

Suresh M. Tuwar¹  Mahesh M. Shanbhag²  Vinoda B. Patil³  Rakesh R. Sawkar³  Tejraj M. Aminabhavi³  Nagaraj P. Shetti⁴ 

[1] Corresponding authors.;Center for Electrochemical Science and Materials, Department of Chemistry, K.L.E. Institute of Technology, Hubballi 580027, Karnataka, India;Department of Chemistry, Karnatak Science College, Dharwad 580001, Karnataka, India;School of Advanced Sciences, KLE Technological University, Vidyanagar, Hubballi 580031, Karnataka, India;

关键词: Electroanalysis;    Ketorolac;    Voltammetry;    Pencil graphite electrode;    Limit of detection;   

DOI  :  

来源: DOAJ

【 摘 要 】

The ketorolac (KEC) is a non-steroidal anti-inflammatory drug (NSAID) which is a water-soluble non-opioid analgesic drug that exhibits antipyretic properties that helps in the treatment concerned with pain. The reports were found on the adverse effect of overdosage of KEC on health which makes to develop the simple, sensitive, and economic electroanalytical method for the trace level detection of KEC. In the present study, pencil graphite was employed as the electrode (PGE) for the electrochemical detection of KEC. The effects of different electrochemical parameters viz., pH of electrolyte, scan rate, and concentration etc., on KEC were explored through cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The irreversible electrochemical reaction governed by the electrode process governed by the diffusion was attained by KEC at PGE. The linearity range was between 2.0 × 10−6 and 1.0 × 10−3 M, while the limit of detection was 4.59 × 10−7 M. The efficiency of the PGE was determined by analysing KEC in pharmaceutical drugs, and spiked real samples. The capability of the PGE towards the detection of KEC in presence of other chemicals was investigated by conducting an interference study. Hence, the proposed method can be applied for the determination of KEC in real biological and clinical samples.

【 授权许可】

Unknown