Pyridazino-1,3a,6a-Triazapentalenes as Versatile Fluorescent Probes: Impact of Their Post-Functionalization and Application for Cellular Imaging

International Journal of Molecular Sciences

Stéphane Petoud¹  Ivana Martinić¹  Svetlana V. Eliseeva¹  Marie-Aude Hiebel²  Doina Sirbu²  Nicolas Chopin²  Franck Suzenet²  Moussa Ndiaye² 

[1] Centre de Biophysique Moléculaire CNRS UPR 4301, Rue Charles Sadron, CEDEX 2, 45071 Orléans, France;Institut de Chimie Organique et Analytique—ICOA UMR7311, Rue de Chartres, CEDEX 2, 45100 Orléans, France;

关键词: pyridazino-1,3a,6a-triazapentalenes;    fluorophores;    photostability;    cell imaging;    fluorescence;   

DOI  :  10.3390/ijms22126645

来源: DOAJ

【 摘 要 】

Pyridazino-1,3a,6a-triazapentalenes (PyTAP) are compact fused 6/5/5 tricyclic scaffolds which exhibit promising fluorescent properties. Chemically stable, they can be post-functionalized using standard Pd-catalyzed cross-coupling chemistry. Several original PyTAP bearing additional unsaturated substituents in positions 2 and 8 were synthetized and their spectroscopic properties analyzed. They have been successfully tested as fluorescent probes for cellular imaging.

【 授权许可】

Unknown