Liposomes: Clinical Applications and Potential for Image-Guided Drug Delivery

Molecules

Srinivasa R. Raghavan¹  Warren D. D’Souza²  Narottam Lamichhane²  Jerimy Polf²  Charles B. Simone II²  Javed Mahmood²  Thirupandiyur S. Udayakumar³ 

[1] Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD 20742, USA;Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA;Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL 33136, USA;

关键词: liposomes;    clinical applications;    image guidance;    radioisotopes;    PET;    SPECT;    MRI;   

DOI  :  10.3390/molecules23020288

来源: DOAJ

【 摘 要 】

Liposomes have been extensively studied and are used in the treatment of several diseases. Liposomes improve the therapeutic efficacy by enhancing drug absorption while avoiding or minimizing rapid degradation and side effects, prolonging the biological half-life and reducing toxicity. The unique feature of liposomes is that they are biocompatible and biodegradable lipids, and are inert and non-immunogenic. Liposomes can compartmentalize and solubilize both hydrophilic and hydrophobic materials. All these properties of liposomes and their flexibility for surface modification to add targeting moieties make liposomes more attractive candidates for use as drug delivery vehicles. There are many novel liposomal formulations that are in various stages of development, to enhance therapeutic effectiveness of new and established drugs that are in preclinical and clinical trials. Recent developments in multimodality imaging to better diagnose disease and monitor treatments embarked on using liposomes as diagnostic tool. Conjugating liposomes with different labeling probes enables precise localization of these liposomal formulations using various modalities such as PET, SPECT, and MRI. In this review, we will briefly review the clinical applications of liposomal formulation and their potential imaging properties.

【 授权许可】

Unknown