Deep Venous Thrombosis and Risk of Consequent Sepsis Event: A Retrospective Nationwide Population-Based Cohort Study

International Journal of Environmental Research and Public Health

Sheng-En Tsai¹  Liang-Tsai Yeh¹  Nai-Chen Shih²  Yu-Hsun Wang³  Ying-Tung Yeh⁴  Ying-Cheng Chen⁵  Shun-Fa Yang⁵  Bo-Yuan Wang⁵  Chao-Bin Yeh⁵  Yin-Yang Chen⁵  Han-Wei Yeh⁶ 

[1] Department of Anesthesiology, Changhua Christian Hospital, Changhua 50006, Taiwan;Department of Family Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan;Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan;Graduate School of Dentistry, School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan;Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan;School of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan;

关键词: sepsis;    deep vein thrombosis;    cohort study;   

DOI  :  10.3390/ijerph18157879

来源: DOAJ

【 摘 要 】

Deep vein thrombosis causes several acute and chronic vessel complications and puts patients at risk of subsequent sepsis development. This unique study aimed to estimate the risk of sepsis development in DVT patients compared with non-DVT patients. This population-based cohort study used records of a longitudinal health insurance database containing two million patients defined in Taiwan’s National Health Insurance Research Database (NHIRD). Our study included patients aged over 20 years with a new diagnosis of DVT with at least two outpatient department visits or an admission between 2001 and 2014. Patients with a diagnosis of sepsis before the index date were excluded. Propensity score matching (PSM) was used to homogenize the baseline characteristics between the two groups. To define the independent risk of the DVT group, a multivariate Cox proportional hazard model was used to estimate the hazard ratios. After PSM, the DVT group (n = 5753) exhibited a higher risk of sepsis (adjusted hazard ratio, aHR, 1.74; 95% CI, 1.59–1.90) compared with non-DVT group (n = 5753). Patients with an increased risk of sepsis were associated with being elderly aged, male, having diabetes, chronic kidney disease, chronic obstructive pulmonary disease, stroke, malignancy, and use of antibiotics. In conclusion, this population-based cohort study demonstrated an increased risk of sepsis in DVT patients compared with non-DVT patients. Thus, early prevention and adequate treatment of DVT is necessary in clinical practice.

【 授权许可】

Unknown