Assessment of enhanced influenza vaccination finds that FluAd conveys an advantage in mice and older adults

Clinical & Translational Immunology

Asmaa Hachim¹  Carolyn A Cohen¹  Sophie A Valkenburg¹  Niloufar Kavian¹  Athena PY Li¹  Alex WH Chin²  Vicky J Fang²  Benjamin J Cowling²  Leo LM Poon²  Nancy HL Leung² 

[1] HKU‐Pasteur Research Pole School of Public Health The University of Hong Kong Hong Kong;World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control School of Public Health The University of Hong Kong Hong Kong;

关键词: adjuvant;    antibody;    B cell;    HA stem;    infection;    influenza vaccine;   

DOI  :  10.1002/cti2.1107

来源: DOAJ

【 摘 要 】

Abstract Objectives Enhanced inactivated influenza vaccines (eIIV) aim to increase immunogenicity and protection compared with the widely used standard IIV (S‐IIV). Methods We tested four vaccines in parallel, FluZone high dose, FluBlok and FluAd versus S‐IIV in a randomised controlled trial of older adults and in a mouse infection model to assess immunogenicity, protection from lethal challenge and mechanisms of action. Results In older adults, FluAd vaccination stimulated a superior antibody profile, including H3‐HA antibodies that were elevated for up to 1 year after vaccination, higher avidity H3HA IgG and larger HA stem IgG responses. In a mouse model, FluAd also elicited an earlier and larger induction of HA stem antibodies with increased germinal centre responses and upregulation and long‐term expression of B‐cell switch transcription factors. Long‐term cross‐reactive memory responses were sustained by FluAd following lethal heterosubtypic influenza challenge, with reduced lung damage and viral loads, coinciding with increased T‐ and B‐cell recall. Advantages were also noted for the high‐dose FluZone vaccine in both humans and mice. Conclusion The early, broadly reactive and long‐lived antibody response of FluAd indicates a potential advantage of this vaccine, particularly in years when there is a mismatch between the vaccine strain and the circulating strain of influenza viruses.

【 授权许可】

Unknown