Dissociation and Brain Rhythms: Pitfalls and Promises

Frontiers in Psychiatry

Lucia Melloni³  Tineke Grent-'t-Jong⁴  Peter J. Uhlhaas⁴ 

[1] Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany;Department of Neurology, New York University School of Medicine, New York, NY, United States;Department of Neuroscience, Max Planck Institute for Empirical Aesthetics, Frankfurt Am Main, Germany;Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom;

关键词: dissociation;    ketamine;    neural oscillations;    optogenetics;    animal models;    translational neuroscience;   

DOI  :  10.3389/fpsyt.2021.790372

来源: DOAJ

【 摘 要 】

Recently, Vesuna et al. proposed a novel circuit mechanism underlying dissociative states using optogenetics and pharmacology in mice in combination with intracranial recordings and electrical stimulation in an epilepsy patient. Specifically, the authors identified a posteromedial cortical delta-rhythm that underlies states of dissociation. In the following, we would like to critically review these findings in the context of the human literature on dissociation as well as highlight the challenges in translational neuroscience to link complex behavioral phenotypes in psychiatric syndromes to circumscribed circuit mechanisms.

【 授权许可】

Unknown