Myeloid derived suppressor cells as therapeutic target in hematological malignancies

Frontiers in Oncology

Ivan eVan Riet¹  Xenia eGeeraerts²  Qods eLahmar²  Jo A Van Ginderachter²  Els eVan Valckenborgh³  Elke eDe Bruyne³  Kim eDe Veirman³  Eline eMenu³  Karin eVanderkerken³ 

[1] Universitair Ziekenhuis Brussel (UZ Brussel);VIB;Vrije Universiteit Brussel;

关键词: Leukemia;    Lymphoma;    Multiple Myeloma;    Stem Cell Transplantation;    immune suppression mechanism;    myeloid derived suppressor cells;   

DOI  :  10.3389/fonc.2014.00349

来源: DOAJ

【 摘 要 】

Myeloid derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells that accumulate during pathological conditions such as cancer and are associated with a poor clinical outcome. MDSC expansion hampers the host anti-tumor immune response by inhibition of T cell proliferation, cytokine secretion and recruitment of regulatory T cells. In addition, MDSC exert non-immunological functions including the promotion of angiogenesis, tumor invasion and metastasis. Recent years, MDSC are considered as a potential target in solid tumors and hematological malignancies to enhance the effects of currently used immune modulating agents. This review focuses on the characteristics, distribution, functions, cell-cell interactions and targeting of MDSC in hematological malignancies including multiple myeloma, lymphoma and leukemia.

【 授权许可】

Unknown