Biocompatibility and osteoconductivity of scaffold porous composite collagen–hydroxyapatite based coral for bone regeneration

Open Chemistry

Kulsum Umi¹  Apsari Retna²  Aminatun Aminatun²  Siswanto Siswanto²  Rudyardjo Djony Izak²  Hikmawati Dyah² 

[1] Biomedical Engineering Program Study, Department of Physics, Faculty of Science and Technology, Universitas Airlangga, Kampus C, Jalan Mulyorejo Surabaya, East Java, 60116, Indonesia;Department of Physics, Faculty of Science and Technology, Universitas Airlangga, Kampus C, Jalan Mulyorejo, Surabaya, East Java, 60116, Indonesia;

关键词: biocompatibility;    osteoconductivity;    composite;    coral;   

DOI  :  10.1515/chem-2020-0080

来源: DOAJ

【 摘 要 】

The synthesis of collagen–hydroxyapatite composites has been carried out, and the biocompatibility and osteoconductivity properties have been tested. This research was conducted to determine the ability of hydroxyapatite–collagen composites to support the bone growth through the graft surface. Hydroxyapatite used in this study was synthesized from coral with a purity of 96.6%, while collagen was extracted from the chicken claw. The process of forming a scaffold of collagen–hydroxyapatite composites was carried out using the freeze-drying method at −80°C for 4 h. The biocompatibility characteristics of the sample through the cytotoxicity tests showed that the percentage of viable cells in collagen–hydroxyapatite biocomposite was 108.2%, which is higher than the percentage of viable cells of hydroxyapatite or collagen material. When the viable cell is above 100%, collagen–hydroxyapatite composites have excellent osteoconductivity as a material for bone regeneration.

【 授权许可】

Unknown