Antimicrobial peptides: mechanism of action, activity and clinical potential

Military Medical Research

Gang Shao¹  Jun Liu²  Jian Kang³  Jun-Jie Ma⁴  Xu-Rui Cheng⁴  Zhi-Bin Yan⁴  Cai-Yun Fu⁴  Qi-Yu Zhang⁴  Yue-Ming Meng⁴  Xiang-Yu Hong⁴ 

[1] Department of Oncology, The 903rd Hospital of PLA;Department of Pharmaceutical Chemistry and the Cardiovascular Research Institute, University of California San Francisco;Oncogenic Signaling and Growth Control Program, Peter MacCallum Cancer Centre;Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University;

关键词: Antimicrobial peptides;    Antimicrobial resistance;    Mechanism of action;    Biological activity;    Clinical application;   

DOI  :  10.1186/s40779-021-00343-2

来源: DOAJ

【 摘 要 】

Abstract The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity. These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action. This comprehensive review provides a broad overview of AMPs from the origin, structural characteristics, mechanisms of action, biological activities to clinical applications. We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics.

【 授权许可】

Unknown