From Emollients to Biologicals: Targeting Atopic Dermatitis

International Journal of Molecular Sciences

Francesco Annunziato¹  Lorenzo Cosmi¹  Lorenzo Salvati¹ 

[1] Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy;

关键词: atopic dermatitis;    therapy;    skin;    type 2 inflammation;    emollients;    barrier repair therapy;   

DOI  :  10.3390/ijms221910381

来源: DOAJ

【 摘 要 】

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and significantly impacts patients’ lives, particularly in its severe forms. AD clinical presentation varies over the course of the disease, throughout different age groups, and across ethnicities. AD is characterized by a spectrum of clinical phenotypes as well as endotypes. Starting from the current description of AD pathogenesis, this review explores the rationale of approved AD therapies from emollients to biologicals and introduces novel promising drugs.

【 授权许可】

Unknown