Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus

Adipocyte

Baosheng Zhao¹  Chen Wang²  Yongcheng An²  Pengfei Li³  Yaqi Li³  Yinglan Lv³  Long Cheng³  Jingkang Wang³  Lu Shi³  Yuhui Duan³  Hongyu Dai³  Huimin Li³  Quantao Ma³  Haifeng Du⁴ 

[1] Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine;College of Life Sciences, Beijing University of Chinese Medicine;School of Chinese Materia Medica, Beijing University of Chinese Medicine;The Third Municipal Hospital of Chengde;

关键词: brown adipose tissue;    beige adipose tissue;    white adipose tissue;    browning of white adipose tissue;    obesity;    type 2 diabetes mellitus;   

DOI  :  10.1080/21623945.2020.1870060

来源: DOAJ

【 摘 要 】

Mammalian adipose tissue can be divided into two major types, namely, white adipose tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function of WAT is to store excess energy in the form of triglycerides, while BAT is a thermogenic tissue that acts a pivotal part in maintaining the core body temperature. White adipocytes display high plasticity and can transdifferentiate into beige adipocytes which have many similar morphological and functional properties with brown adipocytes under the stimulations of exercise, cold exposure and other factors. This phenomenon is also known as ‘browning of WAT’. In addition to transdifferentiation, beige adipocytes can also come from de novo differentiation from tissue-resident progenitors. Activating BAT and inducing browning of WAT can accelerate the intake of glycolipids and reduce the insulin secretion requirement, which may be a new strategy to improve glycolipids metabolism and insulin resistance of obese and type 2 diabetes mellitus (T2DM) patients. This review mainly discusses the significance of brown and beige adipose tissues in the treatment of obesity and T2DM, and focuses on the effect of the browning agent on obesity and T2DM, which provides a brand-new theoretical reference for the prevention and treatment of obesity and T2DM.

【 授权许可】

Unknown