Predictive value of LDL/HDL ratio in coronary atherosclerotic heart disease

BMC Cardiovascular Disorders

Huanhuan Shen¹  PingYin²  Ting Sun²  Li Fan²  Zuojun Xu²  Xin Chen²  Junfeng Zhang²  Jun Wu³  Mengyun Chen⁴ 

[1] Community Health Service Center;Department of Cardiology, Shanghai Ninth People’s Hospital Affiliated With Shanghai Jiao Tong University School of Medicine;Department of Laboratory Medicine, Shanghai General Hospital Jiading Branch;Huamu Community Health Service Center;

关键词: LDL/HDL ratio;    Coronary atherosclerotic heart disease;    Risks;   

DOI  :  10.1186/s12872-022-02706-6

来源: DOAJ

【 摘 要 】

Abstract Background Dyslipidemia is one of independent risk factors for coronary atherosclerotic heart disease (CAHD). We determined whether the LDL/HDL ratio is better than LDL-C or HDL-C alone in predicting the severity of CAHD. Methods We performed a retrospective study of 1351 patients with myocardial ischemia who underwent coronary angiography between January 2018 and December 2019 in Shanghai Ninth People’s Hospital. Spearman correlation analysis, logistic regression model, Cox proportional hazards model and multicollinearity were used to evaluate LDL/HDL ratio for predicting CAHD severity compared to LDL-C or HDL-C alone. Results Higher LDL/HDL ratio was seen in CAHD patients than controls (2.94 ± 1.06 vs 2.36 ± 0.78, P < 0.05). LDL/HDL ratio was significantly associated with the severity of coronary vascular stenosis. The area under the ROC curve of LDL-C, HDL-C, LDL/HDL ratio used to predict CAHD are 0.574 (95% CI 0.547–0.600, P < 0.001), 0.625 (95% CI 0.598–0.651, P < 0.001), 0.668 (95% CI 0.639–0.697, P = 0.000), respectively. The cut-off value of LDL/HDL ratio is 2.517, and the sensitivity and specificity are 65% and 61%, respectively. LDL/HDL ratio was related to the prevalence of CAHD and the odds ratio (OR) was 2.39 [95% confidence interval (CI) 1.698–2.593, P = 0.00] in multicollinearity regression model. Conclusion LDL/HDL ratio may become a better predictor of CAHD severity, compared to LDL-C or HDL-C.

【 授权许可】

Unknown