Effects of Metronidazole as an Adjunct to Non-Surgical Periodontal Therapy on Insulin Resistance in Type 2 Diabetics

Antibiotics

Zeba Haque¹  Ambrina Qureshi²  Hina Qureshi³  Waqas Ahmed Farooqui⁴ 

[1] Department of Biochemistry, Dow International Medical College, Dow University of Health Sciences, Karachi 74200, Pakistan;Department of Community & Preventive Dentistry, Dow University of Health Sciences, Karachi 74200, Pakistan;Department of Pathology, The Kidney Center Postgraduate Institute, Karachi 75260, Pakistan;School of Public Health, Dow University of Health Sciences, Karachi 74200, Pakistan;

关键词: non-surgical periodontal therapy;    insulin resistance;    antibiotics;    type 2 diabetes mellitus;    clinical trial;   

DOI  :  10.3390/antibiotics10111400

来源: DOAJ

【 摘 要 】

Treating periodontitis with metronidazole (MET) as an adjunct to scaling root planing (SRP) is suggested to have inconsistent effects on insulin resistance (IR) in type 2 diabetes mellitus (T2DM). This paper will present the effects of MET, in addition to SRP, on the homeostatis model assessment of IR (HOMA-IR). A three-arm clinical trial was conducted and analyses were performed on T2DM participants with periodontitis (n = 74) who completed follow-up visits at 3 and 6 months after the intervention. The observed between-group and within-group mean changes in IR were found using ANOVA with repeated measures, followed by a post-hoc analysis, and a p-value of ≤0.05 was considered significant. Between-group analyses showed no difference in the HOMA-IR at 3 months, but at 6 months the difference was significant (p = 0.046). Within-group analyses showed that the HOMA-IR was significantly reduced in both test groups (p ≤ 0.05) over the period of time. Adjunct use of MET may result in a sudden short-term lowering of the HOMA-IR level within 3 months that may not be retained over 6 months when compared to the sustained lowering of the HOMA-IR levels in T2DM when intervened with SRP without MET.

【 授权许可】

Unknown