Effectiveness and Safety of Robotic Radiosurgery for Optic Nerve Sheath Meningiomas: A Single Institution Series

Cancers

Franziska Loebel¹  Peter Vajkoczy¹  Markus Kufeld¹  Zoe Zimmermann¹  Alfredo Conti¹  Gueliz Acker¹  Carolin Senger²  Anita Kreimeier²  Anne Kluge²  Melina Kord²  Volker Budach²  Carmen Stromberger² 

[1] Charité Cyberknife Center, Augustenburger Platz 1, 13353 Berlin, Germany;Department of Radiation Oncology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353 Berlin, Germany;

关键词: Cyberknife;    robotic radiosurgery;    stereotactic radiosurgery;    optic nerve sheath meningioma;    hypofractionation;    multisession;   

DOI  :  10.3390/cancers13092165

来源: DOAJ

【 摘 要 】

The role of robotic radiosurgery (RRS) in the treatment of optic nerve sheath meningiomas (ONSM) remains controversial and it is only performed in specialized institutions due to tight dose constraints. We evaluated the effectiveness and safety of RRS in the management of ONSM. Twenty-five patients with 27 ONSM lesions who underwent RRS using the Cyberknife (CK) system were retrospectively analyzed (median age, 47.9 years; 84.0% women). Multisession RRS was used with 4–5 fractions with a cumulative dose of 20.0–25.0 Gy in 84.0% of patients and a single fraction at a dose of 14.0–15.0 Gy in 16% of patients. Prior to RRS, seven (28%) patients experienced blindness on the lesion side. In those patients with preserved vision prior to radiosurgery, the visual acuity remained the same in 90.0% and improved in 10.0% of the patients. Overall local tumor control was 96.0% (mean follow-up period; 37.4 ± 27.2 months). Neither patient age, previous surgery, or the period from the initial diagnosis to RRS showed a dependency on visual acuity before or after radiosurgery. RRS is a safe and effective treatment for the management of ONSM. Hypofractionation of radiosurgery in patients with preserved vision before CK treatment results in stable or improved vision.

【 授权许可】

Unknown