Association between lipoproteins and telomere length in US adults: data from the NHANES 1999–2002

Lipids in Health and Disease

Kai-Wen Zhou¹  Gui-zhen Yang¹  Yun-Fen Chen²  Chi Chen³ 

[1] Department of Immunology and Microbiology and Statistical Epidemiology, Guizhou University of Traditional Chinese Medicine;Department of Nephropathy of the people’s hospital of Guizhou province;School of Medicine and Nursing of Dezhou College;

关键词: Lipoprotein;    Telomere length;    Association;    Nonlinearity;    NHANES database;   

DOI  :  10.1186/s12944-019-1030-7

来源: DOAJ

【 摘 要 】

Abstract Background Evidence regarding the correlation between lipoproteins and telomere length in US adults is limited. We aimed to investigate whether lipoproteins was associated with telomere length using US National Health and Nutrition Examination Survey (NHANES) database. Methods A total of 6468 selected participants were identified in the NHANES Data Base (1999–2002). The independent and dependent variables were lipoproteins and telomere length, respectively. The covariates included demographic data, dietary data, physical examination data, and comorbidities. Results In fully-adjusted model, we found that 0.1 differences of telomere length were positively associated with HDL-C [0.19 (95% CI 0.07, 0.31)], while the associations between LDL-C [0.19 (95% CI -0.27, 0.65)], TG [− 1.00 (95% CI -2.09, 0.07) and telomere length were not detected. By nonlinearity test, only the relationship between HDL-C and telomere length was nonlinear. The inflection point we got was 1.25. On the left side of the inflection point (telomere length ≤ 1.25), a difference in 0.1 of telomere length was associated with 0.50 difference in HDL-C. Conclusion After adjusting for demographic data, dietary data, physical examination data, and comorbidities, telomere length is not associated with LDL-C and TG, but is positively associated with HDL-C when telomere length is less than 1.25.

【 授权许可】

Unknown