Association between triglyceride-glucose index and risk of incident diabetes: a secondary analysis based on a Chinese cohort study

Lipids in Health and Disease

Guilong Li¹  Jing Liu²  Tiantian Cheng³  Xiaoli Li⁴  Guangyao Song⁴  Huijuan Ma⁵ 

[1]Department of Cardiology, Xingtai Third Hospital, 054000, Xingtai, Hebei, China

[2]Department of Endocrinology and Metabolic Diseases, Hebei General Hospital, 050051, Shijiazhuang, Hebei, China

[3]Department of Endocrinology and Metabolic Diseases, Hebei General Hospital, 050051, Shijiazhuang, Hebei, China

[4]Clinical Medical College, North China University of Science and Technology, 063210, Tangshan, Hebei, China

[5]Department of Internal Medicine, Hebei Medical University, 050017, Shijiazhuang, Hebei, China

[6]Department of Endocrinology and Metabolic Diseases, Hebei General Hospital, 050051, Shijiazhuang, Hebei, China

[7]Department of Internal Medicine, Hebei Medical University, 050017, Shijiazhuang, Hebei, China

[8]Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, 050051, Shijiazhuang, Hebei, China

关键词: Triglyceride-glucose index;    Incident diabetes;    Association;    Nonlinearity;    Insulin resistance;    Cohort study;    Chinese adults;   

DOI  :  10.1186/s12944-020-01403-7

来源: Springer

【 摘 要 】

BackgroundRecent studies have suggested the triglyceride-glucose index (TyG index) may serve as a suitable substitute for insulin resistance. However, evidence for the relationship between TyG index and risk of diabetes remains limited. This study sought to explore the association of baseline TyG index with risk of developing diabetes in Chinese adults.MethodsThis retrospective cohort study was conducted using data from the health screening program in China. A total of 201,298 non-diabetic individuals were included. TyG index was calculated as Ln [fasting plasma glucose (mg/dL) × fasting triglyceride level (mg/dL) / 2]. Diabetes was defined as fasting plasma glucose ≥126 mg/dL and/or self-reported diabetes. Cox proportion-hazard model was employed to evaluate the independent impact of baseline TyG index on future diabetes risk. Sensitivity and subgroup analyses were implemented to verify the reliability of results. Notably, data were downloaded from the DATADRYAD website, and used only for secondary analyses.ResultsDuring an average follow-up of 3.12 years, among 201,298 individuals aged ≥20 years, 3389 subjects developed diabetes. After adjusting for potential confounders, elevated TyG index were independently correlated with greater risk of incident diabetes (hazard ratio (HR), 3.34; 95% confidence interval (CI), 3.11–3.60). Compared with the lowest quartile (Q1), increasing TyG index (Q2, Q3, and Q4) was related to increased HR estimates of incident diabetes [HR (95% CI), 1.83 (1.49–2.26); 3.29 (2.70–4.01), and 6.26 (5.15–7.60), respectively]. Moreover, a nonlinear relationship was observed between TyG index and risk of diabetes and the slope of the curve increased accompanying the rise of TyG index. Subgroup analysis revealed the positive association was stronger among subjects with age < 40 years, body mass index ≥18.5 kg/m2 and < 24 kg/m2, or systolic blood pressure < 140 mmHg, or in females.ConclusionsElevated TyG index is independently correlated with increased risk of incident diabetes in Chinese adults, indicating it may represent a reliable predictor of diabetes in high-risk populations.

【 授权许可】

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