The Periodontopathic Pathogen, Porphyromonas gingivalis, Involves a Gut Inflammatory Response and Exacerbates Inflammatory Bowel Disease

Pathogens

Yu-Chen Lee¹  Chia-Long Lee²  Chi-Jung Huang³  Ting-Lin Yen⁴  Chih-Yi Liu⁵  Ruo-Han Zhang⁶ 

[1] Department of Dentistry, Cathay General Hospital, Taipei 106, Taiwan;Department of Internal Medicine, Cathay General Hospital, Taipei 106, Taiwan;Department of Medical Research, Cathay General Hospital, Taipei 106, Taiwan;Department of Oral Hygiene Care, Ching Kuo Institute of Management and Health, Keelung City 20301, Taiwan;Division of Pathology, Sijhih Cathay General Hospital, New Taipei City 221, Taiwan;Graduate School of Health Industry Management, Ching Kuo Institute of Management and Health, Keelung City 20301, Taiwan;

关键词: periodontal disease;    Porphyromonas gingivalis;    inflammatory bowel disease;    gut inflammation;   

DOI  :  10.3390/pathogens11010084

来源: DOAJ

【 摘 要 】

Periodontal disease (PD) is one of the most prevalent disorders globally and is strongly associated with many other diseases. Inflammatory bowel disease (IBD), an inflammatory condition of the colon and the small intestine, is reported to be associated with PD through undetermined mechanisms. We analyzed taxonomic assignment files from the Crohn’s Disease Viral and Microbial Metagenome Project (PRJEB3206). The abundance of Porphyromonadaceae in fecal samples was significantly different between patients with Crohn’s disease and control volunteers. Dextran sulfate sodium was used to induce colitis in mice to reveal the effect of this periodontopathic pathogen in vivo. After intrarectal implantation of Porphyromonas gingivalis (Pg)—the primary pathogen causing PD—the disease activity index score, colonic epithelial loss, and inflammatory cell infiltration were intensified. In addition, tumor necrosis factor-α and interleukin-6 showed the highest levels in Pg-infected colons. This revealed the importance of Pg in the exacerbation of IBD. Thus, simultaneous treatment of PD should be considered for people with IBD. Moreover, implantation of Pg in the rectum worsened the clinical symptoms of colitis in mice. Because Pg participates in the pathogenesis of IBD, reducing the chances of it entering the intestine might prevent the worsening of this disorder.

【 授权许可】

Unknown