Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans

Journal of Clinical Medicine

Eduardo Gómez-Bañuelos¹  Amarshi Mukherjee¹  Erika Darrah¹  Felipe Andrade¹ 

[1] Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA;

关键词: Rheumatoid arthritis;    Porphyromonas gingivalis;    Aggregatibacter actinomycetemcomitans;    periodontitis;    periodontal disease;    citrullination;    peptidylarginine deiminase;    ACPA;    anti-CCP;   

DOI  :  10.3390/jcm8091309

来源: DOAJ

【 摘 要 】

Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology characterized by immune-mediated damage of synovial joints and antibodies to citrullinated antigens. Periodontal disease, a bacterial-induced inflammatory disease of the periodontium, is commonly observed in RA and has implicated periodontal pathogens as potential triggers of the disease. In particular, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans have gained interest as microbial candidates involved in RA pathogenesis by inducing the production of citrullinated antigens. Here, we will discuss the clinical and mechanistic evidence surrounding the role of these periodontal bacteria in RA pathogenesis, which highlights a key area for the treatment and preventive interventions in RA.

【 授权许可】

Unknown