Metastases with definitive pathological diagnosis but no detectable primary tumor: A surveillance epidemiology and end results‐based study

Cancer Medicine

Yadong Dong¹  Guanjing Tian¹  Lianyuan Tao¹  Zhiyuan Ren¹  Haibo Yu¹  Deyu Li¹ 

[1] Department of Hepatobiliary Surgery Henan Provincial People's Hospital People's Hospital of Zhengzhou University, School of Clinical Medicine Henan University Zhengzhou China;

关键词: cancer of unknown primary site;    metastasis;    prognosis;    SEER;    survival;   

DOI  :  10.1002/cam4.2496

来源: DOAJ

【 摘 要 】

Abstract Background This study investigates the characteristics of a special type of cancer of unknown primary site (CUP, type 2), which is a metastasis of a definite pathological diagnosis without a detectable primary site. Patients and methods Patients diagnosed between 2004 and 2014 were identified from the Surveillance Epidemiology and End Results (SEER) database. The characteristics of type 2 CUP from different sources were analyzed. For each source of type 2 CUP, tumors of the corresponding TnN0‐XM1 stage were used as controls. Results A total of 8505 patients with type 2 CUP were included in this analysis. Type 2 CUP shows an increasing trend, while type 1 shows the opposite. Type 2 CUPs have significant differences with stage IV of the same pathological primary lesion. Many characteristics influenced the prognosis of type 2 CUP patients, including marital status, age, race, sex, registration time, lymph node metastasis, surgery, chemotherapy, and radiation. Conclusion Our study suggests that identifying the source of metastasis is the key to the selection of treatment and the determination of the prognosis for CUP.

【 授权许可】

Unknown