Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer

Molecular Therapy: Oncolytics

Wanpeng Yu¹  Wei Ding²  Ying Liu³  Yuan Zhang⁴  Jianxun Wang⁵  Xiang Ao⁶ 

[1] Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao University, Qingdao 266021, China;School of Basic Medical Sciences, Qingdao Medical College, Qingdao University, Qingdao 266071, China;Department of Cardiovascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266000, China;Department of Comprehensive Internal Medicine, Affiliated Hospital, Qingdao University, Qingdao 266003, China;Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao University, Qingdao 266021, China;School of Basic Medical Sciences, Qingdao Medical College, Qingdao University, Qingdao 266071, China;

关键词: long non-coding RNA;    biogenesis;    biomarker;    therapeutic target;    gastric cancer;   

DOI  :  

来源: DOAJ

【 摘 要 】

Gastric cancer (GC) is one of the most prevalent malignant tumor types and the third leading cause of cancer-related death worldwide. Its morbidity and mortality are very high due to a lack of understanding about its pathogenesis and the slow development of novel therapeutic strategies. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs with a length of more than 200 nt. They play crucial roles in a wide spectrum of physiological and pathological processes by regulating the expression of genes involved in proliferation, differentiation, apoptosis, cell cycle, invasion, metastasis, DNA damage, and carcinogenesis. The aberrant expression of lncRNAs has been found in various cancer types. A growing amount of evidence demonstrates that lncRNAs are involved in many aspects of GC pathogenesis, including its occurrence, metastasis, and recurrence, indicating their potential role as novel biomarkers in the diagnosis, prognosis, and therapeutic targets of GC. This review systematically summarizes the biogenesis, biological properties, and functions of lncRNAs and highlights their critical role and clinical significance in GC. This information may contribute to the development of better diagnostics and treatments for GC.

【 授权许可】

Unknown