LncRNA LUCRC Regulates Colorectal Cancer Cell Growth and Tumorigenesis by Targeting Endoplasmic Reticulum Stress Response

Frontiers in Genetics

卷:10

Xiu-Sheng He¹  Guo-Hui Tang²  Xiao-Ting Lin³  Lu Xia³  Feng Ye³  Jia-Bian Lian³  Jun Du⁴  Jian-Cheng Ding⁴  Xue Chen⁴  Wen Liu⁶ 

[1] Cancer Research Institute of Hengyang Medical College, University of South China, Hengyang, China;

[2] Department of Anus and Bowels, Affiliated Nanhua Hospital, University of South China, Hengyang, China;

[3] Department of Medical Oncology, The First Affiliated Hospital of Xiamen University, Xiamen, China;

[4] Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China;

[5] Hunan Provincial Key Laboratory of Cancer Cellular and Molecular Pathology, University of South China, Hengyang, China;

[6] State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China;

关键词: colorectal cancer;    long non-coding RNA;    unfolded protein response;    cell growth;    therapeutic target;   

DOI  :  10.3389/fgene.2019.01409

来源: DOAJ

【 摘 要 】

Colorectal cancer (CRC) is the second most common cause of cancer-related death worldwide, and is well known for its strong invasiveness, rapid recurrence, and poor prognosis. Long non-coding RNAs (lncRNAs) have been shown to be involved in the development of various types of cancers, including colorectal cancer. Here, through transcriptomic analysis and functional screening, we reported that lncRNA LUCRC (LncRNA Upregulated in Colorectal Cancer) is highly expressed in colorectal tumor samples and is required for colorectal cancer cell proliferation, migration, and invasion in cultured cells and tumorigenesis in xenografts. LUCRC was found to regulate target gene expression of unfolded protein response (UPR) in endoplasmic reticulum (ER), such as BIP. The clinical significance of LUCRC is underscored by the specific presence of LUCRC in blood plasma of patients with colorectal cancers. These findings revealed a critical regulator of colorectal cancer development, which might serve as a therapeutic target in colorectal cancer.

【 授权许可】

Unknown