Prediction of Quality of Life in Patients With Parkinson’s Disease With and Without Excessive Daytime Sleepiness: A Longitudinal Study

Frontiers in Aging Neuroscience

Yilin Tang¹  Jian Wang¹  Xiaoniu Liang¹  Lan Wang²  Yajing Chen³  Lixia Zhang⁴  Xiaodong Zhu⁵ 

[1] Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China;Department of Neurology, Nanjing Drum Tower Hospital, Nanjing, China;Department of Neurology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Department of Neurology, Taizhou Second People’s Hospital, Taizhou, China;Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China;

关键词: Parkinson’s disease;    excessive daytime sleepiness;    quality of life;    non-motor symptoms;    motor subtype;   

DOI  :  10.3389/fnagi.2022.846563

来源: DOAJ

【 摘 要 】

ObjectiveThere is a lack of longitudinal studies that directly compare the quality of life (QoL) and investigate the impact of clinical factors on QoL across different excessive daytime sleepiness (EDS) statuses in Parkinson’s disease (PD); therefore, we aimed to compare QoL and reveal the potential heterogeneous predictors of QoL between patients with PD with and without EDS.MethodsWe collected clinical data among 306 patients with PD over 2 years. EDS was assessed by the Epworth Sleepiness Scale and QoL was measured with the 39-item Parkinson’s Disease Questionnaire.ResultsWe found that at both baseline and follow-up, patients with PD with EDS had poorer QoL and suffered more non-motor symptoms including depression and clinical probable rapid eye movement sleep behavior disorder (cpRBD). The generalized linear mixed model analysis indicated that the major predictors of QoL in PD with EDS were the akinetic-rigid type, disease duration, and total levodopa equivalent dose, while in PD without EDS, the primary determinants of QoL were Hoehn and Yahr, Mini-Mental State Examination (MMSE), and cpRBD.ConclusionPatients with PD with EDS presented with poorer QoL. Besides, the baseline predictors of future QoL differed between patients with PD with and without EDS. These findings remind clinicians to target specific clinical factors when attempting to improve QoL among patients with PD.

【 授权许可】

Unknown