Anti-Inflammatory and Antinociceptive Effects of Ethyl Acetate Fraction of an Edible Red Macroalgae Sarcodia ceylanica

International Journal of Molecular Sciences

Hsiao-Mei Kuo¹  Shi-Ying Huang²  Chi-I Chang³  Chieh-Chih Shih⁴  Kuan-Hao Tsui⁵  Hwong-Ru Hwang⁶  Yu-Chi Lin⁷  Pei-Chin Chen⁸  Zhi-Hong Wen⁸  Hui-Min David Wang⁹  Pei-Jyuan Li^1,10  Huei-Meei Su^1,11 

[1] Center for Neuroscience, National Sun Yat-sen University, Kaohsiung 80424, Taiwan;College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China;Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan;Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan;Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan;Division of Cardiology, Department of Internal Medicine, Pingtung Christian Hospital, Pingtung 90059, Taiwan;Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan;Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 80424, Taiwan;Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung 40227, Taiwan;Marine Biomedical Laboratory and Center for Translational Biopharmaceuticals, Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan;Tungkang Biotechnology Research Center, Fisheries Research Institute, Council of Agriculture, Pingtung 92845, Taiwan;

关键词: Sarcodia ceylanica;    carrageenan;    pain;    leukocyte infiltration;    oral;   

DOI  :  10.3390/ijms18112437

来源: DOAJ

【 摘 要 】

Research so far has only shown that edible red macroalgae, Sarcodia ceylanica has the ability to eliminate free radicals and anti-diabetic, anti-bacterial properties. This study was conducted both in vitro and in vivo on the ethyl acetate extract (PD1) of farmed red macroalgae in order to explore its anti-inflammatory properties. In order to study the in vitro anti-inflammatory effects of PD1, we used lipopolysaccharide (LPS) to induce inflammatory responses in murine macrophages. For evaluating the potential in vivo anti-inflammatory and antinociceptive effects of PD1, we used carrageenan-induced rat paw edema to produce inflammatory pain. The in vitro results indicated that PD1 inhibited the LPS-induced pro-inflammatory protein, inducible nitric oxide synthase (iNOS) in macrophages. Oral PD1 can reduce carrageenan-induced paw edema and inflammatory nociception. PD1 can significantly inhibit carrageenan-induced leukocyte infiltration, as well as the protein expression of inflammatory mediators (iNOS, interleukin-1β, and myeloperoxidase) in inflammatory tissue. The above results indicated that PD1 has great potential to be turned into a functional food or used in the development of new anti-inflammatory and antinociceptive agents. The results from this study are expected to help scientists in the continued development of Sarcodia ceylanica for other biomedical applications.

【 授权许可】

Unknown