Vitamin D Receptor TaqI Gene Variant in Exon 9 and Polycystic Ovary Syndrome Risk

International Journal of Fertility and Sterility

Nima Hosseini Jazani¹  Isa Abdi Rad²  Fariba Nanbakhsh²  Morteza Bagheri³ 

[1] Cellular and Molecular Research Center, Urmia University of Med;Department of Genetics, Urmia University of Medical Sciences, Urmia, Iran;Food and Beverages Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran;

关键词: vitamin d receptor;    polycystic ovary syndrome;    genetic variation;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background:Polycystic ovary syndrome (PCOS) is known as a metabolic disorder.The results of recent studies implied that vitamin D receptor (VDR) geneticvariants may impact PCOS and insulin resistance in women with PCOS. The aimof the present study was to determine the VDR TaqI gene variant in exon 9 (T/C)(rs731236) in normal controls and patients with PCOS for the first time in IranianAzeri women.Materials and Methods:In this case control study between April 2011 and June 2012,a total of 76 women aged 18-40 years (38 patients with PCOS and 38 healthy womenas normal controls) participated. Genotypes of VDR TaqI in exon 9 (T/C) (rs731236)were determined using the PCR-RFLP method.Results:The frequencies of VDR TaqI T anc C alleles were 0.605 and 0.395 in casesand 0.697 and 0.303 in controls. Also, the genotypic frequencies of VDR TaqI were16) (42.11), 14(36.84), and 8(21.05) in cases, and 17(44.74), 19(50), and 2(5.26)in controls for TT, TC and CC genotypes respectively. There was no difference ingenotype and allele frequencies between PCOS and controls (p value>0.05) withthe exception of the CC genotype (p value=0.04).Conclusion:This report, a first of its own kind in Iranian Azeri patients, suggests that theCC genotype of VDR TaqI in exon 9 (rs731236) is associated with PCOS.

【 授权许可】

Unknown