The relationship between vitamin D receptor gene polymorphism and retinopathy in type 2 diabetic patients

Guoji Yanke Zazhi

Hui-Li Tian¹  Kai Yan²  Yi Liu³ 

[1] Department of Ophthalmology, Pingdingshan Disabled Persons' Federation Low Vision Rehabilitation Center, Pingdingshan 467000, Henan Province, China;Pingdingshan Polytechnic College, Pingdingshan 467000, Henan Province, China;Zhengzhou Railway Vocational & Technical College, Zhengzhou 451460, Henan Province, China;

关键词: vitamin d receptor;    gene polymorphism;    type 2 diabetes;    retinopathy;   

DOI  :  10.3980/j.issn.1672-5123.2020.8.23

来源: DOAJ

【 摘 要 】

AIM: To investigate the relationship between vitamin D receptor gene polymorphism and retinopathy in patients with type 2 diabetes mellitus.

METHODS: Totally 198 T2DM patients admitted to our hospital from February 2018 to January 2019 were selected as the study objects and divided into DR group(n=108)and non DR group(n=90). The polymorphisms of rs1544410 and rs2228570 were detected by PCR restriction fragment length polymorphism. The relationship between rs1544410, rs2228570 gene polymorphism and retinopathy in type 2 diabetic patients was analyzed by unconditional Logistic regression.

RESULTS: The frequencies of T allele at rs1544410 and A allele at rs2228570 in DR group were significantly higher than those in non DR group(P<0.05). There were 130 cases of CC genotype, 52 cases of CT genotype, 16 cases of TT genotype, and there were statistical differences between CC genotype and CT+TT genotype(P<0.05); 121 cases of GG genotype, 59 cases of GA genotype,18 cases of AA genotype, and there were statistical differences between GG genotype and GA+AA genotype(P<0.05); CT+TT genotype of BSMI gene and GA+AA genotype of FokI gene were risk factors of DR(P<0.05).

CONCLUSION: The polymorphism of VDR gene BSMI and FokI is significantly related to type 2 diabetic retinopathy, which may be the susceptible gene locus of type 2 diabetic retinopathy.

【 授权许可】

Unknown