A Facile One-pot Synthesis of 1-Arylpyrazolo[3,4-d]Pyrimidin- 4-ones

Molecules

关键词: POCl3;    one-pot;    RCOOH;    pyrazolo[3,4-d]pyrimidine;   

DOI  :  10.3390/molecules15053079

来源: DOAJ

【 摘 要 】

One pot synthesis of 1-arylpyrazolo[3,4-d]pyrimidin-4-ones by the reaction of 5-amino-N-substituted-1H-pyrazole-4-carbonitrile with different lower aliphatic acids in the presence of POCl3has been developed. The structures of all the title compounds have been confirmed by IR, 1H-NMR, 13C-NMR, and elemental analyses. Moreover, the structures of one of these compounds, 2c, was confirmed by single-crystal X-ray diffraction.

【 授权许可】

Unknown